Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR004782)
Formula
SVG example
O-glucuronidation
Reactant Mirabegron Product Mirabegron M11 metabolite
Reactant Info Product Info
Metabolic Enzyme UDP-glucuronosyltransferase 2B7 (UGT2B7) DME Info
Metabolic Type Conjugation - O-glucuronidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR004784 Mirabegron Mirabegron M12 metabolite Multi-steps Reaction - Glucuronidation; oxidation Mirabegron [1]
MR004783 Mirabegron Mirabegron M13 metabolite Conjugation - Glucuronidation Mirabegron [1]
MR004780 Mirabegron Mirabegron M14 metabolite Conjugation - N-glucuronidation Mirabegron [1]
MR004781 Mirabegron Mirabegron M15 metabolite Multi-steps Reaction - N-oxidation; glucuronidation Mirabegron [2]
MR004777 Mirabegron Mirabegron M16 metabolite Oxidation - Amide Hydrolyzation Mirabegron [2]
MR004775 Mirabegron Mirabegron M8 metabolite Multi-steps Reaction - Carboxylic acid formation; dealkylation Mirabegron [2]
References
1 Identification of Uridine 5'-Diphosphate-Glucuronosyltransferases Responsible for the Glucuronidation of Mirabegron, a Potent and Selective (3)-Adrenoceptor Agonist, in Human Liver Microsomes
2 Absorption, metabolism and excretion of [(14)C]mirabegron (YM178), a potent and selective (3)-adrenoceptor agonist, after oral administration to healthy male volunteers

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