Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR004817)
Formula
CEH
SVG example
Hydrolyzation
Reactant Mycophenolate mofetil Product N-(2-carboxymethyl)-morpholine
Reactant Info Product Info
Metabolic Enzyme Carboxylic ester hydrolase (CEH) DME Info
Metabolic Type Hydrolysis - Hydrolyzation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR004820 Mycophenolate mofetil 7-O-glucoside Unclear Mycophenolate mofetil [1]
MR004821 Mycophenolate mofetil Acyl glucuronide Unclear Mycophenolate mofetil [1]
MR004811 Mycophenolate mofetil Mycophenolic acid Unclear Mycophenolate mofetil [2], [3], [4]
MR004815 Mycophenolate mofetil Mycophenolic acid glucuronide Conjugation - Glucuronidation Mycophenolate mofetil [4]
MR004816 Mycophenolate mofetil Mycophenolic acyl-glucuronide (AcMPAG) Conjugation - Glucuronidation Mycophenolate mofetil [4]
MR004818 Mycophenolate mofetil N-(2-hydroxyethyl)-morpholine Unclear Mycophenolate mofetil [4]
MR004819 Mycophenolate mofetil N-(2-hydroxyethyl)-morpholine N-oxide Unclear Mycophenolate mofetil [4]
References
1 Mycophenolate mofetil in organ transplantation: focus on metabolism, safety and tolerability
2 The emergence of mycophenolate mofetilin dermatology: from its roots in the world of organ transplantation to its versatile role in the dermatology treatment room
3 The evolution of population pharmacokinetic models to describe the enterohepatic recycling of mycophenolic acid in solid organ transplantation and autoimmune disease. Clin Pharmacokinet. 2011 Jan;50(1):1-24.
4 PharmGKB summary: mycophenolic acid pathway. Pharmacogenet Genomics. 2014 Jan;24(1):73-9.

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