Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR005064)
Formula Reactant 3-hydroxyguanfacine Product Guanfacine 3-glucuronide
Reactant Info Product Info
Metabolic Type Conjugation - O-glucuronidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR010578 Guanfacine 3-Hydroxyguanfacine Oxidation - Oxidation Guanfacine [1]
MR005062 Guanfacine hydrochloride 3-hydroxyguanfacine Oxidation - Oxidationn Guanfacine hydrochloride [2], [3]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR011444 3-hydroxyGuanfacine Glucuronide of hydroxy-Guanfacine Conjugation - Glucuronidation Guanfacine [1]
MR005063 3-hydroxyguanfacine Guanfacine 3-sulfate Conjugation - Sulfation Guanfacine hydrochloride [4]
MR010579 3-Hydroxyguanfacine Guanfacine Metabolite M2 Conjugation - Glucuronidation Guanfacine [1]
MR010580 3-Hydroxyguanfacine Guanfacine Metabolite M3 Conjugation - Sulfation Guanfacine [1]
MR011445 3-hydroxyGuanfacine Sulfate of hydroxy-Guanfacine Conjugation - Sulfation Guanfacine [1]
References
1 Metabolite profiling of guanfacine in plasma and urine of healthy Japanese subjects after oral administration of guanfacine extended-release tablets
2 Determination of 3-hydroxy-guanfacine in biological fluids by electron-capture gas-liquid chromatography
3 Pharmacokinetics and metabolism of guanfacine in man: a review
4 DrugBank(Pharmacology-Metabolism):Guanfacine hydrochloride

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