Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR005134)
Formula Reactant Cortisone Product 6alpha-hydroxy hydrocortisone
Reactant Info Product Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR005133 Cortisone 5-alpha Tetrahydrocortisol Reduction - Reduction Hydrocortisone [1], [2]
MR005132 Cortisone 5-beta Tetrahydrocortisol Reduction - Reduction Hydrocortisone [1], [2]
MR005131 Cortisone 6-beta-hydrocortisol Oxidation - 6-beta-hydroxylation Hydrocortisone [3]
MR010825 Cortisone Cortisol Unclear - Unclear Cortisone [4]
MR010828 Cortisone Tetrahydrocortisone(THE) Unclear - Unclear Cortisone [4]
MR005129 Cortisone Dihydrocortisol Reduction - Reduction Hydrocortisone [5]
MR005130 Cortisone Tetrahydrocortisone Reduction - Reduction Hydrocortisone [5]
References
1 Cortisol metabolism in healthy young adults: sexual dimorphism in activities of A-ring reductases, but not 11beta-hydroxysteroid dehydrogenases
2 Subcellular distribution of 3H--hydrocortisone and its metabolites in the liver and kidneys of normal and alloxan diabetic rats
3 Cortisol metabolism in vitro--III. Inhibition of microsomal 6 beta-hydroxylase and cytosolic 4-ene-reductase. J Steroid Biochem Mol Biol. 1993 Dec;46(6):827-32.
4 Long-term magnesium supplementation improves glucocorticoid metabolism: A post-hoc analysis of an intervention trial
5 DrugBank(Pharmacology-Metabolism):Hydrocortisone

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