Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR005269)
Formula Reactant Tegafur Product 5'-hydroxytegafur
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 2A6 (CYP2A6) DME Info
Metabolic Type Oxidation - 5-hydroxylation
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR005270 5'-hydroxytegafur Fluorouracil Other reaction - Degradation Tegafur [1], [2]
References
1 Summary of information on human CYP enzymes: human P450 metabolism data. Drug Metab Rev. 2002 Feb-May;34(1-2):83-448.
2 Roles of cytochromes P450 1A2, 2A6, and 2C8 in 5-fluorouracil formation from tegafur, an anticancer prodrug, in human liver microsomes. Drug Metab Dispos. 2000 Dec;28(12):1457-63.

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