Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR005279)
Formula
SVG example
Hydrolyzationn
Reactant Tegafur-uracil Product 3-hydroxytegafur
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 2A6 (CYP2A6) DME Info
Metabolic Type Oxidation - Hydrolyzationn
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR005280 Tegafur-uracil 4-hydroxytegafur Oxidation - Hydrolyzationn Tegafur-uracil [1]
MR005271 Tegafur-uracil 5-hydroxytegafur Oxidation - Hydrolyzationn Tegafur-uracil [1]
MR005281 Tegafur-uracil Dihydrotegafur Oxidation - Hydrolyzationn Tegafur-uracil [2], [3], [4]
References
1 DrugBank(Pharmacology-Metabolism):Tegafur-uracil
2 Summary of information on human CYP enzymes: human P450 metabolism data. Drug Metab Rev. 2002 Feb-May;34(1-2):83-448.
3 Roles of cytochromes P450 1A2, 2A6, and 2C8 in 5-fluorouracil formation from tegafur, an anticancer prodrug, in human liver microsomes. Drug Metab Dispos. 2000 Dec;28(12):1457-63.
4 Comparative pharmacology of oral fluoropyrimidines: a focus on pharmacokinetics, pharmacodynamics and pharmacomodulation

If you find any error in data or bug in web service, please kindly report it to Dr. Yin and Dr. Li.