Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR005414)
Formula
UGT1A9 ...
SVG example
Reactant Dihydroartemisinin Product Dihydroartemisinin Glucuronide
Reactant Info Product Info
Metabolic Enzyme UDP-glucuronosyltransferase 1A9 (UGT1A9) DME Info
UDP-glucuronosyltransferase 2B7 (UGT2B7) DME Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000298 Artemether Dihydroartemisinin Oxidation - Oxidation Artemether [1]
MR005413 Artesunate Dihydroartemisinin Unclear Artesunate [2], [3]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR005415 Dihydroartemisinin Glucuronide Furano Acetate of Dihydroartemisinin Unclear Artesunate [4]
References
1 Use of a physiologically-based pharmacokinetic model to simulate artemether dose adjustment for overcoming the drug-drug interaction with efavirenz In Silico Pharmacol. 2013 Mar 1;1:4. doi: 10.1186/2193-9616-1-4.
2 Predicting the Disposition of the Antimalarial Drug Artesunate and Its Active Metabolite Dihydroartemisinin Using Physiologically Based Pharmacokinetic Modeling
3 Review of the clinical pharmacokinetics of artesunate and its active metabolite dihydroartemisinin following intravenous, intramuscular, oral or rectal administration
4 Glucuronidation of dihydroartemisinin in vivo and by human liver microsomes and expressed UDP-glucuronosyltransferases

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