Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR006025)
Formula Reactant Bedaquiline fumarate Metabolite M5 Product Bedaquiline fumarate Metabolite M5-oxime
Reactant Info Product Info
Metabolic Type Oxidation - N-dealkylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006024 Bedaquiline fumarate Bedaquiline fumarate Metabolite M5 Unclear Bedaquiline fumarate [1], [2]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006026 Bedaquiline fumarate Metabolite M5 Bedaquiline fumarate Metabolite M6 Unclear Bedaquiline fumarate [1], [2]
References
1 Bedaquiline metabolism: enzymes and novel metabolites. Drug Metab Dispos. 2014 May;42(5):863-6.
2 Effects of Rifamycin Coadministration on Bedaquiline Desmethylation in Healthy Adult Volunteers

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