Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR006200)
Formula
SVG example
N-demethylation
Reactant Nortrimebutine Product N-didesmethyltrimebutine
Reactant Info Product Info
Metabolic Type Oxidation - N-demethylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006199 Trimebutine Nortrimebutine Oxidation - N-demethylation Trimebutine [1], [2], [3]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006201 Nortrimebutine 2-methylamino-2-phenylbutan-1-ol Hydrolysis - Hydrolysis Trimebutine [1], [2], [3]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006202 N-didesmethyltrimebutine 2-amino-2-phenylbutan-1-ol Hydrolysis - Hydrolysis Trimebutine [1], [2], [3]
References
1 Studies of metabolic pathways of trimebutine by simultaneous administration of trimebutine and its deuterium-labeled metabolite
2 [Metabolism of trimebutine maleate, a gastrointestinal tract motility regulator in rats and mice: characterization and quantification of metabolites in urine, bile and plasma]
3 Quantitative determination of trimebutine maleate and its three metabolites in human plasma by liquid chromatography-tandem mass spectrometry

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