Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR006206)
Formula
SVG example
O-demethylation
Reactant Trimetazidine dihydrochloride Product 2-desmethyltrimetazidine
Reactant Info Product Info
Metabolic Type Oxidation - O-demethylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006209 Trimetazidine dihydrochloride 3-desmethyltrimetazidine Oxidation - O-demethylation Trimetazidine dihydrochloride [1]
MR006212 Trimetazidine dihydrochloride 4-desmethyltrimetazidine Oxidation - O-demethylation Trimetazidine dihydrochloride [1]
MR006217 Trimetazidine dihydrochloride N-acetyltrimetazidine Conjugation - Acetylation Trimetazidine dihydrochloride [1]
MR006216 Trimetazidine dihydrochloride N-formyl Trimetazidine Unclear Trimetazidine dihydrochloride [1]
MR006218 Trimetazidine dihydrochloride N-methyltrimetazidine Conjugation - Methylationn Trimetazidine dihydrochloride [2]
MR006215 Trimetazidine dihydrochloride Trimetazidine Ketopiperazine Oxidation - Oxidationn Trimetazidine dihydrochloride [1]
MR006219 Trimetazidine dihydrochloride Trimetazidine-N-oxide Unclear Trimetazidine dihydrochloride [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006207 2-desmethyltrimetazidine 2-desmethyltrimetazidine O-glucuronide Conjugation - O-glucuronidation Trimetazidine dihydrochloride [1]
MR006208 2-desmethyltrimetazidine 2-desmethyltrimetazidine O-sulphate Conjugation - Sulfation Trimetazidine dihydrochloride [1]
References
1 Identification of trimetazidine metabolites in human urine and plasma
2 Doping control analysis of trimetazidine and characterization of major metabolites using mass spectrometric approaches

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