Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR006775)
Formula Reactant Tolbutamide Product 4-Hydroxy tolbutamide
Reactant Info Product Info
Metabolic Enzyme Mephenytoin 4-hydroxylase (CYP2C19) DME Info
Cytochrome P450 2C9 (CYP2C9) DME Info
Metabolic Type Oxidation - Hydrolyzationn
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006779 Tolbutamide p-Toluenesulfonylurea Unclear Tolbutamide [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006776 4-Hydroxy tolbutamide 1-butyl-3-(p-formylphenyl)sulphonylurea Unclear Tolbutamide [2]
MR006778 4-Hydroxy tolbutamide 4-Carboxytolbutamide Unclear Tolbutamide [1]
References
1 Methyl-hydroxylation and subsequent oxidation to produce carboxylic acid is the major metabolic pathway of tolbutamide in chimeric TK-NOG mice transplanted with human hepatocytes
2 A new aspect of tolbutamide metabolism in the rabbit: the role of 1-butyl-3-(p-formylphenyl)sulphonylurea

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