Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR007158)
Formula
SULT1A1 ...
SVG example
Sulfation
Reactant Ethinylestradiol propanesulfonate Product Ethinylestradiol-3-sulfate
Reactant Info Product Info
Metabolic Enzyme Sulfotransferase 1A1 (SULT1A1) DME Info
Sulfotransferase 1E1 (SULT1E1) DME Info
Metabolic Type Conjugation - Sulfation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR007157 Ethinylestradiol propanesulfonate Ethinylestradiol-glucuronide Conjugation - O-glucuronidation Ethinylestradiol propanesulfonate [1]
MR014077 Ethinylestradiol propanesulfonate Unclear Oxidation - 16alpha-hydroxylation Ethinylestradiol propanesulfonate [1], [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002726 Ethinyl estradiol Ethinylestradiol-3-sulfate Conjugation - Sulfation Ethinyl estradiol [3]
MR001650 17alpha-Ethinylestradiol Ethinylestradiol-3-sulfate Conjugation - Sulfation Mestranol [3]
References
1 Genetic variation in the first-pass metabolism of ethinylestradiol, sex hormone binding globulin levels and venous thrombosis risk Eur J Intern Med. 2017 Jul;42:54-60. doi: 10.1016/j.ejim.2017.05.019.
2 Metabolism of 17 alpha-ethinylestradiol by human liver microsomes in vitro: aromatic hydroxylation and irreversible protein binding of metabolites J Clin Endocrinol Metab. 1974 Dec;39(6):1072-80. doi: 10.1210/jcem-39-6-1072.
3 Sulfotransferase 1E1 is a low km isoform mediating the 3-O-sulfation of ethinyl estradiol Drug Metab Dispos. 2004 Nov;32(11):1299-303. doi: 10.1124/dmd.32.11..

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