Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR007477)
Formula Reactant GSK-1278863 Product GSK-1278863 M7
Reactant Info Product Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR007478 GSK-1278863 GSK-1278863 M13 Unclear GSK-1278863 [1]
MR007472 GSK-1278863 GSK-1278863 M2 Unclear GSK-1278863 [1]
MR007473 GSK-1278863 GSK-1278863 M3 Unclear GSK-1278863 [1]
MR007474 GSK-1278863 GSK-1278863 M4 Unclear GSK-1278863 [1]
MR007475 GSK-1278863 GSK-1278863 M5 Unclear GSK-1278863 [1]
MR007476 GSK-1278863 GSK-1278863 M6 Unclear GSK-1278863 [1]
MR007471 GSK-1278863 Unclear Unclear GSK-1278863 [2]
References
1 Overcoming bioanalytical challenges associated with the separation and quantitation of GSK1278863, a HIF-prolyl hydroxylase inhibitor, and its 14 stereoisomeric metabolites
2 Pharmacokinetics, pharmacodynamics and safety of single, oral doses of GSK1278863, a novel HIF-prolyl hydroxylase inhibitor, in healthy Japanese and Caucasian subjects. Drug Metab Pharmacokinet. 2015 Dec;30(6):410-8.

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