Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR007696)
Formula
SVG example
Elimination
Reactant 7alpha-thiospironolactone Product Canrenone
Reactant Info Product Info
Metabolic Type Other reaction - Elimination
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR007684 Spironolactone 7alpha-thiospironolactone Oxidation - Deacetylation Spironolactone [1], [2]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR007685 7alpha-thiospironolactone 7alpha-thiomethylSpirolactone Hydrolysis - Hydrolysis Spironolactone [3]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR007698 Canrenone 15alpha-OH-canrenone Unclear - Unclear Spironolactone [3]
MR007697 Canrenone Canrenoate Unclear - Unclear Spironolactone [3]
References
1 Conversion of spironolactone to 7 alpha-thiomethylspironolactone by hepatic and renal microsomes
2 Hepatic metabolism of spironolactone. Production of 3-hydroxy-thiomethyl metabolites
3 The metabolism and biopharmaceutics of spironolactone in man

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