Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR008169)
Formula Reactant Tucatinib metabolite M1 Product Tucatinib metabolite M18
Reactant Info Product Info
Metabolic Type Unclear - Unclear
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR008168 Tucatinib Tucatinib metabolite M1 Oxidation - Hydroxylation Tucatinib [1]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR008170 Tucatinib metabolite M1 Tucatinib metabolite M19 Unclear - Unclear Tucatinib [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR008166 Tucatinib metabolite M20 Tucatinib metabolite M18 Unclear - Unclear Tucatinib [1]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR008167 Tucatinib metabolite M18 Tucatinib metabolite M28 Unclear - Unclear Tucatinib [1]
References
1 Elimination of tucatinib, a small molecule kinase inhibitor of HER2, is primarily governed by CYP2C8 enantioselective oxidation of gem-dimethyl

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