Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR008173)
Formula Reactant Tucatinib Product Tucatinib metabolite M31
Reactant Info Product Info
Metabolic Type Oxidation - Dehydrogenation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR008168 Tucatinib Tucatinib metabolite M1 Oxidation - Hydroxylation Tucatinib [1]
MR008163 Tucatinib Tucatinib metabolite M20 Oxidation - Oxidation Tucatinib [1]
MR008174 Tucatinib Tucatinib metabolite M23 Oxidation - Oxidation Tucatinib [1]
MR008171 Tucatinib Tucatinib metabolite M25 Oxidation - Oxazoline ring oxidation Tucatinib [1]
References
1 Elimination of tucatinib, a small molecule kinase inhibitor of HER2, is primarily governed by CYP2C8 enantioselective oxidation of gem-dimethyl

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