Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR008264)
Formula
SVG example
N-demethylation
Reactant S-16020-2 Product S 16018
Reactant Info Product Info
Metabolic Type Oxidation - N-demethylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR008263 S-16020-2 S 16020 glucuronide Unclear - Unclear S-16020-2 [1]
MR008262 S-16020-2 S 18717 Oxidation - N-demethylation S-16020-2 [1]
MR008267 S-16020-2 S 19505 Unclear - Unclear S-16020-2 [1]
MR008265 S-16020-2 S 31919 Conjugation - Sulfation S-16020-2 [1]
MR008266 S-16020-2 Y 874 amide Oxidation - N-oxidation S-16020-2 [1]
References
1 The olivacine derivative s 16020 (9-hydroxy-5,6-dimethyl-N-[2-(dimethylamino)ethyl)-6H-pyrido(4,3-B)-carbazole-1-carboxamide) induces CYP1A and its own metabolism in human hepatocytes in primary culture. Drug Metab Dispos. 2004 Jan;32(1):80-8.

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