Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR008537)
Formula
POR
SVG example
Hydrolysis
Reactant TH-302 Product TH-302 metabolite RM12
Reactant Info Product Info
Metabolic Enzyme NADPH-cytochrome P450 reductase (CPR) DME Info
Metabolic Type Hydrolysis - Hydrolysis
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR008536 TH-302 TH-302 metabolite RM3 Hydrolysis - Hydrolysis TH-302 [1]
MR008526 TH-302 TH-302 metabolite RM9 Conjugation - Glutathione conjugation TH-302 [1]
References
1 Metabolism, pharmacokinetics and excretion of a novel hypoxia activated cytotoxic prodrug, TH-302, in rats

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