Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR008547)
Formula Reactant Beta-D-dioxolane guanosine (DXG) Product DXG-MP
Reactant Info Product Info
Metabolic Enzyme Ecto-5'-nucleotidase (NT5E) DME Info
Deoxyguanosine kinase (DGUOK) DME Info
Metabolic Type Unclear - Unclear
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR008546 Amdoxovir Beta-D-dioxolane guanosine (DXG) Oxidation - Deamination Amdoxovir [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR008548 DXG-MP DXG-DP Unclear - Unclear Amdoxovir [2]
References
1 Lack of pharmacokinetic interaction between amdoxovir and reduced- and standard-dose zidovudine in HIV-1-infected individuals
2 Anabolism of amdoxovir: phosphorylation of dioxolane guanosine and its 5'-phosphates by mammalian phosphotransferases

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