Details of the Metabolic Reaction (MR) | INTEDE

General Information of This Metabolic Reaction (MR) (ID: MR008751)
Formula	CES Hydrolysis
	Reactant	Flumazenil		Product	Ro 15-3690
	Reactant	Reactant Info		Product	Product Info
Metabolic Enzyme	Carboxylesterase (CES)					DME Info
Metabolic Type	Hydrolysis - Hydrolysis

Other MR(s) Related to The Reactant of This MR

Other MR(s) That Metabolize The Reactant of This MR

MR ID	Reactant	Product	MR Type	Related Drug	REF
MR008753	Flumazenil	Ro 15-4965	Unclear - Unclear	Flumazenil	[1]
MR008752	Flumazenil	Ro 15-5526	Oxidation - N-Demethylation	Flumazenil	[1], [2]

References
1	Plasma pharmacokinetics and metabolism of the benzodiazepine antagonist [11C] Ro 15-1788 (flumazenil) in baboon and human during positron emission tomography studies
2	Isolation and pharmacological characterization of microsomal human liver flumazenil carboxylesterase

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