Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR008946)
Formula Reactant PTMA Product 3-OH PDMA
Reactant Info Product Info
Metabolic Type Oxidation - N-demethylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR008945 Neostigmine PTMA Unclear - Unclear Neostigmine [1], [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR004071 3-OH PTMA 3-OH PDMA Unclear W-108598 [2]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR008947 3-OH PDMA Neostigmine metabolite M1 Conjugation - Monoglucosidation Neostigmine [2]
MR004072 3-OH PDMA W-108598 Metabolite W1 Unclear W-108598 [2]
References
1 Metabolites of neostigmine and pyridostigmine do not contribute to antagonism of neuromuscular blockade in the dog
2 Isolation and characterisation of metabolites of neostigmine from rat urine

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