Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR008965)
Formula Reactant Desvenlafaxine Product Cyclohexane ring hydroxy desvenlafaxine
Reactant Info Product Info
Metabolic Type Oxidation - Hydroxylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR008964 Desvenlafaxine Benzyl hydroxy desvenlafaxine Oxidation - Hydroxylation Desvenlafaxine [1]
MR008967 Desvenlafaxine Desvenlafaxine N-oxide Oxidation - N-oxidation Desvenlafaxine [1]
MR008966 Desvenlafaxine Desvenlafaxine O-glucuronide Conjugation - O-glucuronidation Desvenlafaxine [1]
MR008963 Desvenlafaxine N,O-Didesmethylvenlafaxine Oxidation - N-demethylation Desvenlafaxine [1]
MR005638 Desvenlafaxine N,O-Didesmethylvenlafaxine Oxidation - N-demethylation Venlafaxine hydrochloride [2], [3], [4]
MR005641 Desvenlafaxine O-Desmethylvenlafaxine glucuronide Conjugation - Glucuronidation Venlafaxine hydrochloride [2], [3], [4]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000774 Desvenlafaxine succinate Cyclohexane ring hydroxy desvenlafaxine Oxidation - Hydroxylation Desvenlafaxine succinate [5]
References
1 DrugBank(Pharmacology-Metabolism):Desvenlafaxine
2 O- and N-demethylation of venlafaxine in vitro by human liver microsomes and by microsomes from cDNA-transfected cells: effect of metabolic inhibitors and SSRI antidepressants. Neuropsychopharmacology. 1999 May;20(5):480-90.
3 Venlafaxine oxidation in vitro is catalysed by CYP2D6. Br J Clin Pharmacol. 1996 Feb;41(2):149-56.
4 Comparison of the pharmacokinetics of venlafaxine extended release and desvenlafaxine in extensive and poor cytochrome P450 2D6 metabolizers
5 DrugBank(Pharmacology-Metabolism)Desvenlafaxine succinate

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