Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR009102)
Formula Reactant Fidarestat Product Fidarestat Metabolite F17
Reactant Info Product Info
Metabolic Type Oxidation - Dihydroxylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR009091 Fidarestat Fidarestat Metabolite F1 Multi-steps Reaction - Oxidation; deamination Fidarestat [1], [2]
MR009104 Fidarestat Fidarestat Metabolite F11 Multi-steps Reaction - Hydroxylation; glycosylation Fidarestat [1]
MR009101 Fidarestat Fidarestat Metabolite F14 Other reaction - Cysteamination Fidarestat [1]
MR009106 Fidarestat Fidarestat Metabolite F15 Multi-steps Reaction - Hydroxylation; cysteamination Fidarestat [1]
MR009105 Fidarestat Fidarestat Metabolite F16 Conjugation - N-acetylation Fidarestat [1]
MR009103 Fidarestat Fidarestat Metabolite F18 Conjugation - Glucuronidation Fidarestat [1]
MR009097 Fidarestat Fidarestat Metabolite F3 Multi-steps Reaction - Reduction; defluroniation Fidarestat [1]
MR009107 Fidarestat Fidarestat Metabolite F4 Reduction - Hydrogenation Fidarestat [1]
MR009108 Fidarestat Fidarestat Metabolite F5 Oxidation - Trihydroxylation Fidarestat [1]
MR009100 Fidarestat Fidarestat Metabolite F6 Oxidation - Methylation Fidarestat [1]
MR009099 Fidarestat Fidarestat Metabolite F8 Multi-steps Reaction - Oxidation; acetylation Fidarestat [1]
MR009098 Fidarestat Fidarestat Metabolite F9 Conjugation - Glycosylation Fidarestat [1]
References
1 Identification and characterization of in vitro and in vivo fidarestat metabolites: Toxicity and efficacy evaluation of metabolites
2 Plasma protein binding, pharmacokinetics, tissue distribution and CYP450 biotransformation studies of fidarestat by ultra high performance liquid chromatography-high resolution mass spectrometry

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