Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR009118)
Formula
SVG example
Unclear
Reactant GS-441524 Product GS-441524-MP
Reactant Info Product Info
Metabolic Type Unclear - Unclear
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR014047 Remdesivir Alanine Metabolite (Ala-Met; GS-704277) Remdesivir Nucleoside Monophosphate Unclear Remdesivir [1]
MR013219 Remdesivir M1 Remdesivir Nucleoside Monophosphate Unclear Remdesivir [1]
MR013212 Remdesivir Alanine Metabolite (Ala-Met; GS-704277) Remdesivir Nucleoside Monophosphate Oxidation - Deamination Remdesivir [2]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR009119 GS-441524-MP GS-441524-DP Unclear - Unclear GS-441524 [3]
MR014046 Remdesivir Nucleoside Monophosphate GS-441524 Unclear Remdesivir [4]
MR014048 Remdesivir Nucleoside Monophosphate Remdesivir Nucleoside Triphosphate Conjugation - Phosphorylation Remdesivir [5]
MR013214 Remdesivir Nucleoside Monophosphate GS-441524 Unclear Remdesivir [2]
MR013213 Remdesivir Nucleoside Monophosphate Remdesivir Nucleoside Triphosphate Conjugation - Phosphorylation Remdesivir [2]
References
1 Viral target and metabolism-based rationale for combined use of recently authorized small molecule COVID-19 medicines: Molnupiravir, nirmatrelvir, and remdesivir
2 Remdesivir: A Review of Its Discovery and Development Leading to Emergency Use Authorization for Treatment of COVID-19
3 Comparison of anti-SARS-CoV-2 activity and intracellular metabolism of remdesivir and its parent nucleoside
4 Population pharmacokinetic modeling of GS-441524, the active metabolite of remdesivir, in Japanese COVID-19 patients with renal dysfunction
5 Remdesivir: Review of Pharmacology, Pre-clinical Data, and Emerging Clinical Experience for COVID-19

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