Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR009203)
Formula
SVG example
Unclear
Reactant 3,4-Dihydroxycinnamic Acid Product Ferulic acid
Reactant Info Product Info
Metabolic Enzyme Catechol O-methyltransferase (COMT) DME Info
Metabolic Type Unclear - Unclear
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR009212 3,4-Dihydroxycinnamic Acid 3,4-Dihydroxycinnamic Acid Metabolite M Unclear - Unclear 3,4-Dihydroxycinnamic Acid [1]
MR009194 3,4-Dihydroxycinnamic Acid 3-(Dihydroxyphenyl)propanoic acid Reduction - Reduction 3,4-Dihydroxycinnamic Acid [2], [1]
MR009208 3,4-Dihydroxycinnamic Acid Caffeic acid-3'-O-sulfate Unclear - Unclear 3,4-Dihydroxycinnamic Acid [3]
MR009211 3,4-Dihydroxycinnamic Acid Caffeic acid-4'-O-glucuronide Unclear - Unclear 3,4-Dihydroxycinnamic Acid [3]
MR009209 3,4-Dihydroxycinnamic Acid Caffeic acid-4'-O-sulfate Unclear - Unclear 3,4-Dihydroxycinnamic Acid [3]
MR009210 3,4-Dihydroxycinnamic Acid Cis-Caffeic acid Unclear - Unclear 3,4-Dihydroxycinnamic Acid [3]
MR009206 3,4-Dihydroxycinnamic Acid Isoferulic acid Unclear - Unclear 3,4-Dihydroxycinnamic Acid [3]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR011806 NCX 2057 Ferulic acid Unclear - Unclear NCX-1000 [4]
MR009201 DHFA FA Unclear - Unclear 3,4-Dihydroxycinnamic Acid [1]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR009204 Ferulic acid Ferulic acid-4'-O-glucuronide Unclear - Unclear 3,4-Dihydroxycinnamic Acid [3]
MR009205 Ferulic acid Ferulic acid-4'-O-sulfate Unclear - Unclear 3,4-Dihydroxycinnamic Acid [3]
References
1 Metabolism of caffeic acid by isolated rat hepatocytes and subcellular fractions
2 In vitro catabolism of 3',4'-dihydroxycinnamic acid by human colonic microbiota
3 Absorption, disposition, metabolism, and excretion of [3-(14)C]caffeic acid in rats
4 Treatment of portal hypertension with NCX-1000, a liver-specific NO donor. A review of its current status

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