Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR009545)
Formula Reactant Riociguat metabolite M1 Product Riociguat metabolite M4
Reactant Info Product Info
Metabolic Enzyme UDP-glucuronosyltransferase 1A1 (UGT1A1) DME Info
UDP-glucuronosyltransferase 1A9 (UGT1A9) DME Info
Metabolic Type Conjugation - N-glucuronidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR009544 Riociguat Riociguat metabolite M1 Oxidation - N-demethylation Riociguat [1], [2]
References
1 Population pharmacokinetics of riociguat and its metabolite in patients with chronic thromboembolic pulmonary hypertension from routine clinical practice
2 Clinical Pharmacokinetic and Pharmacodynamic Profile of Riociguat

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