Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR009736)
Formula
SVG example
Glucuronidation
Reactant EM-652 Product EM-652-4'-Glucuronide
Reactant Info Product Info
Metabolic Enzyme UDP-glucuronosyltransferase 1A1 (UGT1A1) DME Info
Metabolic Type Conjugation - Glucuronidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR009734 EM-800 EM-652 Unclear - Unclear EM-800 [1]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR009735 EM-652 EM-652-7-Glucuronide Conjugation - Glucuronidation EM-800 [2]
References
1 The interaction of raloxifene and the active metabolite of the antiestrogen EM-800 (SC 5705) with the human estrogen receptor
2 Glucuronidation of the nonsteroidal antiestrogen EM-652 (SCH 57068), by human and monkey steroid conjugating UDP-glucuronosyltransferase enzymes

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