Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR009969)
Formula
SVG example
Hydroxylation
Reactant Mephenytoin Product 4'-hydroxymephenytoin
Reactant Info Product Info
Metabolic Enzyme Mephenytoin 4-hydroxylase (CYP2C19) DME Info
Metabolic Type Oxidation - Hydroxylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR009971 Mephenytoin Nirvanol Oxidation - Demethylation Mephenytoin [1], [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR009970 4'-hydroxymephenytoin Mephenytoin Metabolite M3 Conjugation - Glucuronidation Mephenytoin [1]
References
1 Quantification of mephenytoin and its metabolites 4'-hydroxymephenytoin and nirvanol in human urine using a simple sample processing method
2 Relation of in vivo drug metabolism to stereoselective fetal hydantoin toxicology in mouse: evaluation of mephenytoin and its metabolite, nirvanol

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