Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR010321)
Formula
SVG example
Unclear
Reactant MK-499 Product Glutathione
Reactant Info Product Info
Metabolic Type Unclear - Unclear
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR010317 MK-499 MK-499 Metabolite M1 Unclear - N-substitution MK-499 [1]
MR010318 MK-499 MK-499 Metabolite M2 Oxidation - 4 hydroxylation MK-499 [1]
MR010319 MK-499 MK-499 Metabolite M3 Unclear - Unclear MK-499 [1]
MR010320 MK-499 MK-499 Metabolite M4 Oxidation - 4 hydroxylation MK-499 [1]
MR010323 MK-499 MK-499 Metabolite M7 Conjugation - Glucuronidation MK-499 [1]
MR010322 MK-499 N-acetyl-1-cysteine Unclear - Unclear MK-499 [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR007376 BRN-4179169 Glutathione Unclear BRN-4179169 [2]
MR003897 Gamma-glutamylcysteine Glutathione Unclear E-920 [3]
MR004258 SLG GSH Unclear Methylglyoxal [4]
References
1 Metabolism of MK-499, a class III antiarrhythmic agent, in rats and dogs
2 Non-invasive monitoring of L-2-oxothiazolidine-4-carboxylate metabolism in the rat brain by in vivo 13C magnetic resonance spectroscopy
3 The mercaptopyruvate pathway in cysteine catabolism: a physiologic role and related disease of the multifunctional 3-mercaptopyruvate sulfurtransferase
4 Cells producing their own nemesis: understanding methylglyoxal metabolism

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