Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR010568)
Formula
SVG example
Unclear
Reactant LCZ696 Product Sacubitrilat LBQ657
Reactant Info Product Info
Metabolic Type Unclear - Unclear
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR010567 LCZ696 Valsartan Unclear - Unclear LCZ696 [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR003715 Sacubitril LBQ657 Hydrolysis - Ester hydrolysis LCZ-696 [2], [3], [4]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR003716 LBQ657 LCZ-696 Metabolite M4 Unclear LCZ-696 [4]
MR003717 LBQ657 LCZ-696 Metabolite M5 Unclear LCZ-696 [4]
MR003718 LBQ657 LCZ-696 Metabolite M6 Oxidation - Oxidationn LCZ-696 [4]
MR003719 LBQ657 LCZ-696 Metabolite M7 Oxidation - Oxidationn LCZ-696 [4]
MR003720 LBQ657 LCZ-696 Metabolite M8 Unclear LCZ-696 [4]
References
1 An evaluation of the fixed-dose combination sacubitril/valsartan for the treatment of arterial hypertension
2 Pharmacokinetics and pharmacodynamics of LCZ696, a novel dual-acting angiotensin receptor-neprilysin inhibitor (ARNi)
3 Dicarboxylic acid dipeptide neutral endopeptidase inhibitors
4 Disposition and metabolism of [(14)C] Sacubitril/Valsartan (formerly LCZ696) an angiotensin receptor neprilysin inhibitor, in healthy subjects

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