Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR011495)
Formula Reactant S-297995 Product Naidemedine-3-G
Reactant Info Product Info
Metabolic Enzyme UDP-glucuronosyltransferase 1A3 (UGT1A3) DME Info
Metabolic Type Conjugation - Glucuronide conjugation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR011491 S-297995 Benzamidine Multi-steps Reaction - Reduction; Hydrolysis S-297995 [1]
MR011493 S-297995 Naidemedine-(7R)-7-hydroxide Oxidation - Oxidation S-297995 [1]
MR011494 S-297995 Naidemedine-(7S)-7-hydroxide Oxidation - Oxidation S-297995 [1]
MR011485 S-297995 Naldemedine carboxylic acid Hydrolysis - Hydrolysis S-297995 [1]
MR011489 S-297995 Nor-naldemedine Oxidation - N-dealkylation S-297995 [1]
References
1 Absorption, distribution, metabolism, and excretion of radiolabeled naldemedine in healthy subjects

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