Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR012214)
Formula
SVG example
O-desmethylation
Reactant TR-14035 Product TR-14081
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 2C9 (CYP2C9) DME Info
Metabolic Type Oxidation - O-desmethylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR012217 TR-14035 TR-14516 Oxidation - Hydroxylation TR-14035 [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR012216 TR-14081 TR-14081 sulfate Conjugation - O-sulfate conjugation TR-14035 [1]
MR012215 TR-14081 TR-14331 Oxidation - Di-O-desmethylation TR-14035 [1]
References
1 Pharmacokinetics and metabolism of TR-14035, a novel antagonist of a4ss1/a4ss7 integrin mediated cell adhesion, in rat and dog

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