Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR012957)
Formula Reactant PCI-45741 (M25) Product Ibrutinib Metabolite M20
Reactant Info Product Info
Metabolic Type Oxidation - Hydrolyzationn
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR012956 Ibrutinib PCI-45741 (M25) Multi-steps Reaction - Dehydrogenation; hydroxylation; reduction; oxidation Ibrutinib [1]
References
1 Absorption, metabolism, and excretion of oral 14C radiolabeled ibrutinib: an open-label, phase I, single-dose study in healthy men. Drug Metab Dispos. 2015 Feb;43(2):289-97.

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