Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR013004)
Formula
SVG example
Unclear
Reactant TNP-470 Metabolite MIV Product TNP-470 Metabolite MII
Reactant Info Product Info
Metabolic Enzyme Epoxide hydrolase 1 (EPHX1) DME Info
Metabolic Type Unclear - Unclear
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR013003 TNP-470 TNP-470 Metabolite MIV Unclear - Unclear TNP-470 [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR013005 TNP-470 Metabolite MII TNP-470 Metabolite MIII Unclear - Unclear TNP-470 [2]
References
1 Pharmacokinetics and metabolism of O-(chloroacetyl-carbamoyl) fumagillol (TNP-470, AGM-1470) in rhesus monkeys
2 Phase I dose escalation pharmacokinetics of O-(chloroacetylcarbamoyl) fumagillol (TNP-470) and its metabolites in AIDS patients with Kaposi's sarcoma

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