Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR013126)
Formula	Deacetylation; N-glucuronidation
	Reactant	Trametinib Metabolite M1	Product	Trametinib Metabolite M2
	Reactant	Reactant Info	Product	Product Info
Metabolic Type	Multi-steps Reaction - Deacetylation; N-glucuronidation

Other MR(s) Related to The Reactant of This MR

Other MR(s) That Produce The Reactant of This MR

MR ID	Reactant	Product	MR Type	Related Drug	REF
MR013125	Trametinib	Trametinib Metabolite M1	Oxidation - Deacetylation	Trametinib	[1]

Other MR(s) Related to The Product of This MR

Other MR(s) That Metabolize The Produtc of This MR

MR ID	Reactant	Product	MR Type	Related Drug	REF
MR013128	Trametinib Metabolite M2	Trametinib Metabolite M4	Multi-steps Reaction - Deacetylation, hydroxylation,glucuronidation	Trametinib	[2]

References
1	Pharmacokinetic Interaction Between the MEK1/MEK2 Inhibitor Trametinib and Oral Contraceptives Containing Norethindrone and Ethinyl Estradiol in Female Patients With Solid Tumors
2	Trametinib, a first-in-class oral MEK inhibitor mass balance study with limited enrollment of two male subjects with advanced cancers

If you find any error in data or bug in web service, please kindly report it to Dr. Yin and Dr. Li.