Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR013216)
Formula Reactant Remdesivir Nucleoside Triphosphate Product Remdesivir-DP
Reactant Info Product Info
Metabolic Enzyme 8-oxo-dGDP phosphatase NUDT18 (NUDT18) DME Info
Metabolic Type Hydrolysis - Hydrolysis
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR014048 Remdesivir Nucleoside Monophosphate Remdesivir Nucleoside Triphosphate Conjugation - Phosphorylation Remdesivir [1]
MR013213 Remdesivir Nucleoside Monophosphate Remdesivir Nucleoside Triphosphate Conjugation - Phosphorylation Remdesivir [2]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR013217 Remdesivir Nucleoside Triphosphate Remdesivir-MP Hydrolysis - Hydrolysis Remdesivir [3]
References
1 Remdesivir: Review of Pharmacology, Pre-clinical Data, and Emerging Clinical Experience for COVID-19
2 Remdesivir: A Review of Its Discovery and Development Leading to Emergency Use Authorization for Treatment of COVID-19
3 Nudix hydrolase 18 catalyzes the hydrolysis of active triphosphate metabolites of the antivirals remdesivir, ribavirin, and molnupiravir

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