Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR013254)
Formula
SVG example
Elimination
Reactant R-10(R)-Hydroxywarfarin Product (E)-dehydrowarfarin
Reactant Info Product Info
Metabolic Type Other reaction - Elimination
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR013253 Warfarin sodium R-10(R)-Hydroxywarfarin Oxidation - 10-hydroxylation Warfarin sodium [1], [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR013257 R-10(S)-Hydroxywarfarin (E)-dehydrowarfarin Other reaction - Elimination Warfarin sodium [1], [2]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR013255 (E)-dehydrowarfarin (Z)-dehydrowarfarin Other reaction - Elimination Warfarin sodium [1], [2]
References
1 Comparative pharmacokinetics of vitamin K antagonists: warfarin, phenprocoumon and acenocoumarol. Clin Pharmacokinet. 2005;44(12):1227-46.
2 Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development Curr Med Chem. 2009;16(27):3480-675. doi: 10.2174/092986709789057635.

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