Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR013327)
Formula
UGT
SVG example
Reactant E-3A Product 17alpha-Estradiol-3-glucuronide
Reactant Info Product Info
Metabolic Enzyme UDP-glucuronyltransferase (UGT) DME Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR013329 E-3A 17-beta-estradiol 3-sulfate-17-(beta-D-glucuronide) Unclear E-3A [1]
MR013326 E-3A 17-beta-Estradiol glucuronide Unclear E-3A [2], [3]
MR013324 E-3A 17-beta-Estradiol-3-glucuronide Unclear E-3A [1]
MR013308 E-3A 17beta-Estradiol-3,17-beta-sulfate Unclear E-3A [4]
MR013313 E-3A 2-hydroxyestrone Oxidation - 2-hydroxylation E-3A [5]
MR013325 E-3A 2-methoxy-17beta-estradiol 3-O-(beta-D-glucuronide) Unclear E-3A [2]
MR013323 E-3A 2-Methoxyestrone 3-glucuronide Unclear E-3A [5]
MR013318 E-3A 4-Hydroxyestradiol Unclear E-3A [6]
MR013315 E-3A 4-hydroxyestrone Oxidation - 4-hydroxylation E-3A [6]
MR013328 E-3A Estradiol-17alpha 3-D-glucuronoside Unclear E-3A [1]
MR013322 E-3A Estradiol-17beta 3-sulfate Unclear E-3A [7]
MR013320 E-3A Estrone Unclear E-3A [6]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002632 Estradiol 17alpha-Estradiol-3-glucuronide Unclear Estradiol acetate [2]
MR002656 Estradiol 17alpha-Estradiol-3-glucuronide Unclear Estradiol cypionate [2]
MR002679 Estradiol 17alpha-Estradiol-3-glucuronide Unclear Estradiol valerate [2]
References
1 DrugBank(Pharmacology-Metabolism):E-3A
2 The metabolism of estradiol; oral compared to intravenous administration J Steroid Biochem. 1985 Dec;23(6A):1065-70. doi: 10.1016/0022-4731(85)90068-8.
3 Profiling endogenous serum estrogen and estrogen-glucuronides by liquid chromatography-tandem mass spectrometry Anal Chem. 2009 Dec 15;81(24):10143-8. doi: 10.1021/ac9019126.
4 Cytochrome P450 1A2 (CYP1A2) activity and risk factors for breast cancer: a cross-sectional study. Breast Cancer Res. 2004;6(4):R352-65.
5 DrugBank(Pharmacology-Metabolism)Estradiol acetate
6 Cytochrome P450-mediated metabolism of estrogens and its regulation in human. Cancer Lett. 2005 Sep 28;227(2):115-24.
7 FOODB:E-3A

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