Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR013665)
Formula
SVG example
Reactant GS-606965 Product GS-461203
Reactant Info Product Info
Metabolic Enzyme Uridine/cytidine monophosphate kinase (UMPK) DME Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR013664 GS-56650 GS-606965 Unclear Sofosbuvir [1], [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR009411 RO2433-DP RO2433-TP Unclear - Unclear R7128 [3]
References
1 Pharmacokinetics, safety, and tolerability of GS-9851, a nucleotide analog polymerase inhibitor for hepatitis C virus, following single ascending doses in healthy subjects
2 Mechanism of activation of PSI-7851 and its diastereoisomer PSI-7977. J Biol Chem. 2010 Nov 5;285(45):34337-47.
3 Characterization of the metabolic activation of hepatitis C virus nucleoside inhibitor beta-D-2'-Deoxy-2'-fluoro-2'-C-methylcytidine (PSI-6130) and identification of a novel active 5'-triphosphate species

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