Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR013790)
Formula	Sulfation
	Reactant	Thalfendine	Product	Thalifendine-10-O-sulfate
	Reactant	Reactant Info	Product	Product Info
Metabolic Type	Conjugation - Sulfation

Other MR(s) Related to The Reactant of This MR

Other MR(s) That Produce The Reactant of This MR

MR ID	Reactant	Product	MR Type	Related Drug	REF
MR013789	Berberine	Thalfendine	Oxidation - Demethylation	Berberine	[1], [2], [3]

Other MR(s) That Metabolize The Reactant of This MR

MR ID	Reactant	Product	MR Type	Related Drug	REF
MR013791	Thalfendine	Thalifendine-10-O-beta-D-glucuronide	Conjugation - Glucuronidation	Berberine	[1]

References
1	The metabolism of berberine and its contribution to the pharmacological effects
2	CYP2D plays a major role in berberine metabolism in liver of mice and humans
3	Transformation of berberine to its demethylated metabolites by the CYP51 enzyme in the gut microbiota

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