Detail Information of Xenobiotics

General Information of Xenobiotics (ID: XEO00014)
Xenobiotics Name
Chlorambucil
Xenobiotics Type
Pharmaceutical Agent(s)
Classification
Approved/Marketed Drug
Structure
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3D MOL 2D MOL
PubChem CID
2708
DME(s) Modulated by This Xenobiotics
DME(s) Inhibited by This Xenobiotics
Small intestine reductase (AKR1B10) DME Info Homo sapiens [1]
Aldo-keto reductase 1C2 (AKR1C2) DME Info Homo sapiens [1]
Glutathione S-transferase alpha-1 (GSTA1) DME Info Homo sapiens [2]
References
1 Oxidative stress mechanisms do not discriminate between genotoxic and nongenotoxic liver carcinogens. Chem Res Toxicol. 2015 Aug 17;28(8):1636-46.
2 Role of multidrug resistance protein 1 (MRP1) and glutathione S-transferase A1-1 in alkylating agent resistanceKinetics of glutathione conjugate formation and efflux govern differential cellular sensitivity to chlorambucil versus melphalan toxicity. J Biol Chem. 2001 Mar 16;276(11):7952-6.

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