Detail Information of Xenobiotics

General Information of Xenobiotics (ID: XEO00064)
Xenobiotics Name
Mitotane
Xenobiotics Type
Pharmaceutical Agent(s)
Classification
Approved/Marketed Drug
Structure
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3D MOL 2D MOL
PubChem CID
4211
DME(s) Modulated by This Xenobiotics
DME(s) Inhibited by This Xenobiotics
Cholesterol desmolase (CYP11A1) DME Info Homo sapiens [1]
Steroid 17-alpha-monooxygenase (CYP17A1) DME Info Homo sapiens [2]
Dihydrotestosterone oxidoreductase (HSD3B1) DME Info Homo sapiens [3]
Beta-HSD adrenal and gonadal type (HSD3B2) DME Info Homo sapiens [4]
DME(s) Induced by This Xenobiotics
Cytochrome P450 3A4 (CYP3A4) DME Info Homo sapiens [5]
References
1 Resolving pathways of interaction of mipafox and a sarin analog with human acetylcholinesterase by kinetics, mass spectrometry and molecular modeling approaches. Arch Toxicol. 2016 Mar;90(3):603-16.
2 Mifepristone induced progesterone withdrawal reveals novel regulatory pathways in human endometrium. Mol Hum Reprod. 2007 Sep;13(9):641-54.
3 Phenyl valerate esterase activity of human butyrylcholinesterase. Arch Toxicol. 2017 Oct;91(10):3295-3305.
4 In vitro protection of plasma cholinesterases by metoclopramide from inhibition by mipafox. J Appl Toxicol. 2004 Mar-Apr;24(2):143-6.
5 Influence of progesterone on endometrial nitric oxide synthase expression. Fertil Steril. 2009 May;91(5 Suppl):2157-62.

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