Detail Information of Xenobiotics

General Information of Xenobiotics (ID: XEO00091)
Xenobiotics Name
Estrone
Xenobiotics Type
Pharmaceutical Agent(s)
Classification
Approved/Marketed Drug
Structure
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3D MOL 2D MOL
PubChem CID
5870
DME(s) Modulated by This Xenobiotics
DME(s) Inhibited by This Xenobiotics
Porphobilinogen synthase (ALAD) DME Info Homo sapiens [1]
Aromatase (CYP19A1) DME Info Homo sapiens [2]
Cytochrome P450 1B1 (CYP1B1) DME Info Homo sapiens [3]
Sulfotransferase 1E1 (SULT1E1) DME Info Homo sapiens [4]
Xenobiotics-DME Activity Data
Xenobiotics-DME Activity Data Aromatase (CYP19A1) DME Info Ki = 2.5 microM [2]
Cytochrome P450 1B1 (CYP1B1) DME Info IC50 > 50 microM [3]
References
1 Moving toward integrating gene expression profiling into high-throughput testing: a gene expression biomarker accurately predicts estrogen receptor alpha modulation in a microarray compendium. Toxicol Sci. 2016 May;151(1):88-103.
2 Developing steroidal aromatase inhibitors-an effective armament to win the battle against breast cancer. Eur J Med Chem. 2015 Nov 13;105:1-38.
3 Targeting cytochrome P450 (CYP) 1B1 with steroid derivatives. Bioorg Med Chem Lett. 2016 Nov 1;26(21):5272-5276.
4 Development and validation of a fluorescence HPLC-based screening assay for inhibition of human estrogen sulfotransferase. Anal Biochem. 2006 Oct 1;357(1):85-92.

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