Detail Information of Xenobiotics

General Information of Xenobiotics (ID: XEO00100)
Xenobiotics Name
Pyridostigmine bromide
Xenobiotics Type
Pharmaceutical Agent(s)
Classification
Approved/Marketed Drug
Structure
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3D MOL 2D MOL
PubChem CID
7550
DME(s) Modulated by This Xenobiotics
DME(s) Inhibited by This Xenobiotics
Acetylcholinesterase (ACHE) DME Info Homo sapiens [1]
Cellular glutathione peroxidase (GPX1) DME Info Homo sapiens [2]
DME(s) Induced by This Xenobiotics
Catalase (CAT) DME Info Homo sapiens [3], [2]
Xenobiotics-DME Activity Data
Xenobiotics-DME Activity Data Acetylcholinesterase (ACHE) DME Info IC50 = 0.35 microM [1]
References
1 Novel potent pyridoxine-based inhibitors of AChE and BChE, structural analogs of pyridostigmine, with improved in vivo safety profile. Bioorg Med Chem Lett. 2016 Aug 15;26(16):4092-4.
2 Integrated analysis of microRNA and mRNA expression profiles highlights aldehyde-induced inflammatory responses in cells relevant for lung toxicity. Toxicology. 2015 Aug 6;334:111-21.
3 Transcriptome profile analysis of saturated aliphatic aldehydes reveals carbon number-specific molecules involved in pulmonary toxicity. Chem Res Toxicol. 2014 Aug 18;27(8):1362-70.

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