General Information of Xenobiotics (ID: XEO00174)
Xenobiotics Name
Propylthiouracil
Xenobiotics Type
Pharmaceutical Agent(s)
Classification
Approved/Marketed Drug
Structure
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3D MOL 2D MOL
PubChem CID
657298
DME(s) Modulated by This Xenobiotics
DME(s) Inhibited by This Xenobiotics
Myeloperoxidase (MPO) DME Info Homo sapiens [1]
Xenobiotics-DME Activity Data
Xenobiotics-DME Activity Data Myeloperoxidase (MPO) DME Info IC50 = 2.81 microM [1]
References
1 Discovery of 2-(6-(5-chloro-2-methoxyphenyl)-4-oxo-2-thioxo-3,4-dihydropyrimidin-1(2H)-yl)acetamide (PF-06282999): a highly selective mechanism-based myeloperoxidase inhibitor for the treatment of cardiovascular diseases. J Med Chem. 2015 Nov 12;58(21):8513-28.

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