Detail Information of Xenobiotics

General Information of Xenobiotics (ID: XEO00191)
Xenobiotics Name
Everolimus
Xenobiotics Type
Pharmaceutical Agent(s)
Classification
Approved/Marketed Drug
Structure
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3D MOL 2D MOL
PubChem CID
6442177
DME(s) Modulated by This Xenobiotics
DME(s) Inhibited by This Xenobiotics
Carboxylesterase 1 (CES1) DME Info Homo sapiens [1]
Carboxylesterase 2 (CES2) DME Info Homo sapiens [1]
Nitric oxide synthase endothelial (NOS3) DME Info Homo sapiens [2]
References
1 P-glycoprotein, CYP3A, and plasma carboxylesterase determine brain and blood disposition of the mTOR Inhibitor everolimus (Afinitor) in mice. Clin Cancer Res. 2014 Jun 15;20(12):3133-45.
2 Sirolimus and everolimus induce endothelial cellular senescence via sirtuin 1 down-regulation: therapeutic implication of cilostazol after drug-eluting stent implantation. J Am Coll Cardiol. 2009 Jun 16;53(24):2298-305.

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