Detail Information of Xenobiotics

General Information of Xenobiotics (ID: XEO00192)
Xenobiotics Name
Dutasteride
Xenobiotics Type
Pharmaceutical Agent(s)
Classification
Approved/Marketed Drug
Structure
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3D MOL 2D MOL
PubChem CID
6918296
DME(s) Modulated by This Xenobiotics
DME(s) Inhibited by This Xenobiotics
Delta(24)-sterol reductase (DHCR24) DME Info Homo sapiens [1]
Steroid 5-alpha-reductase 1 (SRD5A1) DME Info Homo sapiens [2]
Steroid 5-alpha-reductase 2 (SRD5A2) DME Info Homo sapiens [2]
DME(s) Induced by This Xenobiotics
Aldo-keto reductase 1C1 (AKR1C1) DME Info Homo sapiens [2]
Aldo-keto reductase 1C2 (AKR1C2) DME Info Homo sapiens [2]
Aldo-keto reductase 1C3 (AKR1C3) DME Info Homo sapiens [2]
Aldosterone synthase (CYP11B2) DME Info Homo sapiens [1]
Estradiol 17-beta-dehydrogenase 1 (HSD17B1) DME Info Homo sapiens [1]
Testicular 17-beta-hydroxysteroid dehydrogenase (HSD17B3) DME Info Homo sapiens [1]
References
1 Effects of dutasteride on the expression of genes related to androgen metabolism and related pathway in human prostate cancer cell lines. Invest New Drugs. 2007 Oct;25(5):491-7.
2 Dutasteride affects progesterone metabolizing enzyme activity/expression in human breast cell lines resulting in suppression of cell proliferation and detachment. J Steroid Biochem Mol Biol. 2006 Aug;100(4-5):129-40.

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