Detail Information of Xenobiotics

General Information of Xenobiotics (ID: XEO00204)
Xenobiotics Name
Piroxicam
Xenobiotics Type
Pharmaceutical Agent(s)
Classification
Approved/Marketed Drug
Structure
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3D MOL 2D MOL
PubChem CID
54676228
DME(s) Modulated by This Xenobiotics
DME(s) Inhibited by This Xenobiotics
Succinic semialdehyde reductase (AKR7A2) DME Info Homo sapiens [1]
Aromatase (CYP19A1) DME Info Homo sapiens [1]
Dicarbonyl/L-xylulose reductase (DCXR) DME Info Homo sapiens [1]
HMG-CoA reductase (HMGCR) DME Info Homo sapiens [2]
Corticosteroid 11-beta-dehydrogenase 1 (HSD11B1) DME Info Homo sapiens [3]
Transglutaminase H (TGM2) DME Info Homo sapiens [4]
References
1 Use of high-throughput enzyme-based assay with xenobiotic metabolic capability to evaluate the inhibition of acetylcholinesterase activity by organophosphorous pesticides. Toxicol In Vitro. 2019 Apr;56:93-100.
2 Major intermediates in organophosphate synthesis (PCl3, POCl3, PSCl3, and their diethyl esters) are anticholinesterase agents directly or on activation. Chem Res Toxicol. 2003 Mar;16(3):350-6.
3 Kinetics and mechanism of inhibition of serine esterases by fluorinated aminophosphonates. Chem Biol Interact. 2010 Sep 6;187(1-3):177-84.
4 Synthesis, biological activity, and preliminary pharmacokinetic evaluation of analogues of a phosphosulfomannan angiogenesis inhibitor (PI-88). J Med Chem. 2005 Dec 29;48(26):8229-36.

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