Detail Information of Xenobiotics

General Information of Xenobiotics (ID: XEO00260)
Xenobiotics Name
Dinoprostone
Xenobiotics Type
Pharmaceutical Agent(s)
Classification
Approved/Marketed Drug
Structure
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3D MOL 2D MOL
PubChem CID
5280360
DME(s) Modulated by This Xenobiotics
DME(s) Inhibited by This Xenobiotics
Corticosteroid 11-beta-dehydrogenase 2 (HSD11B2) DME Info Homo sapiens [1]
DME(s) Induced by This Xenobiotics
Cholesterol desmolase (CYP11A1) DME Info Homo sapiens [2]
Steroid 17-alpha-monooxygenase (CYP17A1) DME Info Homo sapiens [2]
Aromatase (CYP19A1) DME Info Homo sapiens [3]
Cytochrome P450 1B1 (CYP1B1) DME Info Homo sapiens [4]
Corticosteroid 11-beta-dehydrogenase 1 (HSD11B1) DME Info Homo sapiens [5]
Beta-HSD adrenal and gonadal type (HSD3B2) DME Info Homo sapiens [2]
Prostaglandin G/H synthase 2 (COX-2) DME Info Homo sapiens [6], [7]
References
1 Prostaglandins and leukotriene B4 are potent inhibitors of 11beta-hydroxysteroid dehydrogenase type 2 activity in human choriocarcinoma JEG-3 cells. Biol Reprod. 1999 Jul;61(1):40-5.
2 Prostaglandin E2 via steroidogenic factor-1 coordinately regulates transcription of steroidogenic genes necessary for estrogen synthesis in endometriosis. J Clin Endocrinol Metab. 2009 Feb;94(2):623-31.
3 Prostaglandin E2 down-regulates sirtuin 1 (SIRT1), leading to elevated levels of aromatase, providing insights into the obesity-breast cancer connection. J Biol Chem. 2019 Jan 4;294(1):361-371.
4 Prostaglandin E2 induces CYP1B1 expression via ligand-independent activation of the ERalpha pathway in human breast cancer cells. Toxicol Sci. 2010 Apr;114(2):204-16.
5 PTGER1 and PTGER2 receptors mediate regulation of progesterone synthesis and type 1 11beta-hydroxysteroid dehydrogenase activity by prostaglandin E2 in human granulosa lutein cells. J Endocrinol. 2007 Sep;194(3):595-602.
6 Ketoconazole suppresses prostaglandin E(2)-induced cyclooxygenase-2 expression in human epidermoid carcinoma A-431 cells. J Invest Dermatol. 2002 Jul;119(1):174-81.
7 Cyclooxygenase-2 expression by nonsteroidal anti-inflammatory drugs in human airway smooth muscle cells: role of peroxisome proliferator-activated receptors. J Immunol. 2003 Jan 15;170(2):1043-51.

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