Detail Information of Xenobiotics

General Information of Xenobiotics (ID: XEO00365)
Xenobiotics Name
Metformin
Xenobiotics Type
Pharmaceutical Agent(s)
Classification
Approved/Marketed Drug
Structure
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3D MOL 2D MOL
PubChem CID
4091
DME(s) Modulated by This Xenobiotics
DME(s) Inhibited by This Xenobiotics
Catalase (CAT) DME Info Homo sapiens [1]
Cytochrome P450 1B1 (CYP1B1) DME Info Homo sapiens [2]
L-glutamine amidohydrolase (GLS) DME Info Homo sapiens [3]
Quinone reductase 1 (NQO1) DME Info Homo sapiens [4]
Tryptophan oxygenase (TRPO) DME Info Homo sapiens [5]
References
1 Classification of heavy-metal toxicity by human DNA microarray analysis. Environ Sci Technol. 2007 May 15;41(10):3769-74.
2 The human xenobiotic-metabolizing enzyme arylamine N-acetyltransferase 1 (NAT1) is irreversibly inhibited by inorganic (Hg2+) and organic mercury (CH3Hg+): mechanism and kinetics. FEBS Lett. 2010 Aug 4;584(15):3366-9.
3 The activity of erythrocyte enzymes and basic indices of peripheral blood erythrocytes from workers chronically exposed to mercury vapours. Toxicol Ind Health. 2000 Feb;16(2):58-64.
4 Does mercury promote lipid peroxidation? An in vitro study concerning mercury, copper, and iron in peroxidation of low-density lipoprotein. Biol Trace Elem Res. 2004 Nov;101(2):117-32.
5 Microarray analysis of mercury-induced changes in gene expression in human liver carcinoma (HepG2) cells: importance in immune responses. Int J Environ Res Public Health. 2006 Jun;3(2):141-73.

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